Pharmacological characterization of ionophore X537A-induced contractile responses in isolated rabbit taenia coli and aorta.
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چکیده
منابع مشابه
Possible mechanisms of inhibitory action of sodium nitroprusside on histamine-induced contractile responses in isolated rabbit aorta compared with basilar artery and taenia coli.
Possible mechanisms of the inhibitory actions of sodium nitroprusside (NaNP) on histamine-induced contractile responses of isolated rabbit aorta, basilar artery and taenia coli were studied. NaNP (3 X 10(-5) M) reduced maximum contractile response to histamine in the aorta, whereas a concentration (10(-4) M) of NaNP slightly shifted the concentration-response curve for histamine towards its hig...
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It is well known that a-adrenoceptors have been classified into the a1-type in postsynaptic sites and the a2-type in presynaptic sites (1). Prazosin and yohimbine are selective an tagonists of a1 and a2-adrenoceptors, re spectively (2). Norepinephrine (NE) exerts a non-selective agonistic action at each type of a-adrenoceptors (3, 4). Recent reports present evidence that postsynaptic a2 as well...
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Background & Aims: Considering increasing incidence of cardiovascular disorders in diabetes mellitus and some evidence on antioxidant and antidiabetic potentials of naringenin, this study was conducted to evaluate the beneficial effects of 6-week administration of naringenin on contractile reactivity of isolated thoracic aorta in diabetic rats. Methods: Male Wistar rats were divided into contro...
متن کاملExchange diffusion of dopamine induced in planar lipid bilayer membranes by the ionophore X537A
The ionophore X537A causes a large increase in the [(14)C]dopamine (a catecholamine) permeability of planar bilayer membranes. Dopamine transport increases linearly with the ionophore concentration. At relatively high concentrations in the presence of dopamine, the ionophore omdices a conductance which is nearly ideally selective for the dopamine cation. However, the total dopamine flux as dete...
متن کاملPharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Studies were performed in the rabbit aortic rings, precontracted with norepinephrine, to determine the subtype(s) of muscarinic receptors involved in endothelium-dependent relaxation and contraction in the absence of endothelium elicited by cholinergic stimuli. Acetylcholine (ACh) and arecaidine propargyl ester (APE), a M2 and M3 agonist, produced a dose-dependent relaxation and contraction in ...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1983
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.6.39